And it helps wear down their opponents
Standard is the least certain of the bunch, mostly because cards like Magma Spray and Abrade offer the ability to remove every one-mana creature along with some two- and three-mana creatures as well, but when you consider that the next-best options in white are cards like Gideon's Reproach and Slash of Talons (discounting enchantment-based removal like Seal Away, which is probably already in your main deck), the flexibility of killing one-drops and random sideboard hate might be enough for Isolate to sneak into sideboards in small numbers
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"There are still kids now that say, 'Oh my God, I just saw the Black Lotus!'" noted Chang, "And they didn't even grow up with the Black Lotus, but they'll still want to buy one when they grow up because it's like owning a Michael Jordan rookie
